The global UTI crisis

We’re facing a crisis of misdiagnosis, complications, suffering and critical antimicrobial resistance.

In focus:

A painful reality

Urinary Tract Infections (UTIs) cause pain and unnecessary prolonged suffering to millions of people globally. Often mistreated, UTIs are a leading cause of hospital admissions and account for a tremendous 22% of all antibiotic prescriptions. With antimicrobial resistance on the rise, there is no time to spare. We must act now.

400m UTIs globally per year

In 2018, UTIs caused 2.8m hospitalisations in the USA. [1]

>71% women

[2]
Women have a 25% chance of experiencing recurrent infections. [3]

$2.3 billion treatment failure

Annually in the USA.[4]

“If we don’t act now, our medicine cabinet will be empty and we won’t have the antibiotics we need to save lives.”

CDC Director, Tom Frieden, M.D, M.P.H

“The problem is waiting for the results and you're in pain… and you could be getting worse.”

Patient

“If no action is taken, it has been estimated that drug-resistant infections will kill 10 million people a year by 2050.”

Dame Sally Davies, ex-CMO UK

“UTIs have made me sceptical of doctors in a lot of ways.”

Patient

“It is estimated that nearly 50% of all antimicrobial use in hospitals is unnecessary or inappropriate.”

Combating Antimicrobial Resistance: Policy Recommendations to Save Lives, Clinical Infectious Diseases, IDSA, 2011

“I worry that I’ll get something more serious and I can’t be treated for it because of my previous antibiotic use.”

Patient

“If we don’t act now, our medicine cabinet will be empty and we won’t have the antibiotics we need to save lives.”

CDC Director, Tom Frieden, M.D, M.P.H

“The problem is waiting for the results and you're in pain… and you could be getting worse.”

Patient

“If no action is taken, it has been estimated that drug-resistant infections will kill 10 million people a year by 2050.”

Dame Sally Davies, ex-CMO UK

“If we don’t act now, our medicine cabinet will be empty and we won’t have the antibiotics we need to save lives.”

CDC Director, Tom Frieden, M.D, M.P.H

“The problem is waiting for the results and you're in pain… and you could be getting worse.”

Patient

“If no action is taken, it has been estimated that drug-resistant infections will kill 10 million people a year by 2050.”

Dame Sally Davies, ex-CMO UK

“UTIs have made me sceptical of doctors in a lot of ways.”

Patient

“It is estimated that nearly 50% of all antimicrobial use in hospitals is unnecessary or inappropriate.”

Combating Antimicrobial Resistance: Policy Recommendations to Save Lives, Clinical Infectious Diseases, IDSA, 2011

“I worry that I’ll get something more serious and I can’t be treated for it because of my previous antibiotic use.”

Patient

“If we don’t act now, our medicine cabinet will be empty and we won’t have the antibiotics we need to save lives.”

CDC Director, Tom Frieden, M.D, M.P.H

“The problem is waiting for the results and you're in pain… and you could be getting worse.”

Patient

“If no action is taken, it has been estimated that drug-resistant infections will kill 10 million people a year by 2050.”

Dame Sally Davies, ex-CMO UK

A comparison with current care

Enumeration
<10 minutes
Identification
<10 minutes
AST
<60 mins
Point of Care

Empiric prescribing


Enumeration
Based on symptoms only
Identification
Best guess
AST
Point of Care

Dipstick


Enumeration
Biomaker detection
Identification
AST
Point of Care

Traditional culture
(gold standard)

Enumeration
24 hours
Identification
24 - 48 hours
AST
Point of Care

Definitions:

Enumeration
Determination of bacterial presence above a threshold
Identification
ID of the causative pathogen, required for the prescribing decision tree
AST
Antimicrobial Susceptibility Testing -required to determine effective therapy
Point of Care
Healthcare settings where care or treatment is provided

Our solution

InnotiveUTI

InnotiveUTI cartridge

Our flagship innovation brings fast and accurate UTI tests to healthcare providers directly. Clinicians will know the correct antibiotics to prescribe within an hour, so patients get effective treatment.

Use of the InnotiveUTI means fewer repeat visits and hospital admissions, lower rates of recurrent UTIs and preventing the rise of antimicrobial resistance (AMR).

Find out more

Ask us anything

Curious clinicians and interested investors - we’re looking forward to all your questions.

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References:
[1] Zeng et al, 2022, Global, regional, and national burden of urinary tract infections from 1990 to 2019: an analysis of the global burden of disease study 2019. [2] Simmering et al, Hospitalisations for UTI and Associated Costs of Antimicrobial Therapy in the Emergency Department, 2014. [3] Scott et al., 2021: Fear and Frustration among Women with Recurrent Urinary Tract Infections: Findings from Patient Focus Groups, 2017 (quotes from patients and experts). [4] Management estimate.